№22 Май 2022

Будущее митохондриальной терапии

Editorial

Dear readers

Before the 10th anniversary of the Cardiometry journal, the pulse of the time and the expansion of the space of scientific interests for our readers, who play a major role in the life and development of our Journal, are becoming more and more remarkable.

Original research

Structural myocardial catastrophe under the influence of chronic neurogenic pain due to development of B16 melanoma in female mice

Alla I. Shikhlyarova, Elena M. Frantsiyants, Irina V. Kaplieva, Gаlina V. Zhukova, Irina V. Neskubina, Evgenia M. Nepomnyashchaya, Lidia K. Trepitaki, Yulia Yu. Kozel, Marina A. Yengibaryan, Alexandra A. Vereskunova, Stella M. Babieva, Vladislav M. Legostaev, Dmitriy A. Kharagezov, Victoria L. Volkova, Oleg I. Kit

Most of the inhabitants on the planet have directly experienced certain manifestations of pain, and in the case of chronic pain sensations, some significant changes may occur not only in the psycho-emotional sphere of a human individual, but also some functional alterations in the life maintenance systems.

Chronic neurogenic painB16 melanomaHeartMorphological changes in the myocardiumFemale mice

Original research

Mitochondrial therapy of melanoma B16/F10, pathophysiological parameters of tumor regression

Oleg I. Kit, Elena M. Frantsiyants, Alla I. Shikhlyarova, Irina V. Neskubina, Irina V. Kaplieva, Lidia K. Trepitaki, Yulia A. Pogorelova, Natalia D. Cheryarina, Alexandra A. Vereskunova, Valeria A. Bandovkina, Ekaterina I. Surikova, Natalia A. Maksimova, Inga M. Kotieva, Marina A. Gusareva, Viktoria V. Pozdnyakova

The aim is to evaluate the pathophysiological parameters of the efficacy of liver mitochondrial transplantation in animals with B16/F10 melanoma.

Mitochondrial therapyMitochondriaB16/F10 melanomaBALB/c Nude mice

Report

Intelligent digitalization of cardiovascular risks

Yuri Y. Gromov, Aleksei V. Gorbunov, Viacheslav M. Tyutyunnik

The aim of the study was to develop a mathematical model of the risks of the cardiovascular system based on the selected factors affecting cardiovascular diseases (CVD) and to test the developed mathematical model on a sample of clinical examples.

CardiovascularRisk factorsMathematical modelHazard classNeuro-fuzzy classifier

Editorial

Adrenaline heart

Mikhail Y. Rudenko, Irina А. Berseneva, Murat P. Deberdeev, Maria V. Pasikova, Alexander V. Tychinsky, Amalia I. Mitilineo-Obukhova, Botir А. Yuldashev, Malika D. Murodova

The role of adrenaline in the body, especially in athletes, is considered. Special attention is paid to the cardiovascular system performance in conditions of the continuous release of adrenaline. The ECG shape and the possible therapy in case of adrenaline heart are discussed.

AdrenalineCardiovascularHeartECGAthlete

Report

PCI VS CABG FOR PATIENTS WITH CTO: CONTEMPORARY TECHNIQUES AND OUTCOME-SINGLE CENTER EXPERIENCE

Walid Abbas, Bassem Zarif, Ahmed Azmy

CTOs are common findings on coronary arteriograms [1]. CTOs were defined as 100% coronary occlusion present for at least three months and found in almost 20% of all angiograms of patients with angina.

PCICABGCTOCoronary arteriogram

Original research

Comparison of totally automated and manual processing for calculation of left ventricular volumes and ejection fraction using gated myocardial perfusion SPECT

Amirah Fahad Al-Shammari, Uzma Afzal

Gated single-photon emission computed tomography (SPECT) allows for the assessment of myocardial left ventricular ejection fraction and left ventricular volumes. There is conflicting data regarding the difference between automated and manual processing of gated myocardial SPECT images.

Gated SPECTProcessing methodLeft ventricular ejection fractionLeft ventricular volumesMyocardial perfusion

Original research

Interdisciplinary educational approaches in Healthcare Organizations

Mohammed Al Tous, Ahmad Alkhaibary, Hussein Alabssi, Ahmad Haimour, Amal Alqarni, Maissa Alqaryouti

Healthcare professionals' perception of Interdisciplinary Education is an essential factor that affects their acceptance of this approach to education. From the literature related to patient safety, it has been identified widely that healthcare team communication and performance are critical to providing safe care to the patient.

Interdisciplinary educationHealthcare professionalsInter professional collaboration

Original research

Morphological and anatomical study of the new plant collection PHYTOFRUFOL

Manzura T. Mullajonova, Flyura F. Urmanova, Dildora K. Pulatova, Gulzhan M. Duschanova

For the first time, the morphological and anatomical features of the herbal preparation "Phytofrufol", developed on the basis of medicinal plants growing in the conditions of Uzbekistan, were studied.

Lemon balm herbDog rose hipsBlack currant leaves

Original research

A study to identify the impact of Covid-19 on the trust and risk perceptions of online buying behaviour

G. Akshaya, Pushkar Phadtare

Coronavirus has become a global emergency and has left a strong impact on people all over the world. It has altered the way we live, the way we work, and the way we see the world around us.

COVID-19CoronavirusPandemicOnline buying behaviourNew normalSocial distancing

Essay

Elena M. Frantsiyants

Elena M. Frantsiyants, Doctor of Biological Sciences, Professor, Deputy General Director for Science at the National Medical Research Center for Oncology at the Russian Ministry of Health, being a highly qualified expert in the field of pathophysiology and biochemistry of various malignant neoplasms, develops and implements original methods and techniques of laboratory diagnostics and assessing the effectiveness of therapy.

Original research

Mitochondrial therapy: direct visual assessment of the possibility of preventing myocardial infarction under chronic neurogenic pain and B16 melanoma growth in the experiment

Oleg I. Kit, Alla I. Shikhlyarova, Elena M. Frantsiyants, Irina V. Neskubina, Irina V. Kaplieva, Gаlina V. Zhukova, Lidia K. Trepitaki, Yulia A. Pogorelova, Valeria A. Bandovkina, Ekaterina I. Surikova, Ivan A. Popov, Tamara Voronina, Oksana V. Bykadorova, Elizaveta V. Serdyukova

On models of chronic neurogenic pain (CNP) and the growth of a malignant tumor (metastasizing B16 melanoma) in male mice, we studied an effect produced by mitochondrial therapy (MCT) on the state of the myocardium. Some structural correlates of the compensatory-restorative effect by mitochondria transplanted from healthy recipient rats were revealed.

Laboratory miceChronic neurogenic painB16 melanomaMitochondrial therapyMyocardiumPathomorphologyCardiac microscopy

Original research

cAMP сoncentrations in cardiac mitochondria and serum in the С57ВL/6 mice under independent melanoma В16/F10 growth versus melanoma В16/F10 growth linked to chronic neurogenic pain

Oleg I. Kit, Elena M. Frantsiyants, Valeria A. Bandovkina, Irina V. Neskubina, Alla I. Shikhlyarova, Irina V. Kaplieva, Ekaterina I. Surikova, Yulia A. Pogorelova, Natalia D. Cheryarina, Lidia K. Trepitaki, Irina А. Goroshinskaya, Larisa N. Vaschenko, Yuliana S. Shatova, Lyudmila P. Kuchkina, Vera A. Kovalenko

The aim of this research work is to study the cAMP level in the cardiac mitochondria and serum in the С57ВL/6 strain mice of both genders under the independent melanoma В16/F10 growth versus the melanoma В16/F10 growth linked to chronic neurogenic pain (CNP).

B16/F10 melanomaMouse strain C57Bl/6cAMPMitochondriaHeartChronic neurogenic pain

Report

The use of cardiometry in development of self-control skills by means of game sand modeling

Vladimir A. Zernov, Elena V. Lobanova, Elvira V. Likhacheva, Lyubov P. Nikolaeva, Aleksandr S. Ognev, Nadezhda A. Ogneva, Mikhail Y. Rudenko

The article presents experimental evidence of the validity of our hypothesis that progress in the formation and development of self-control can be fixed by assessing heart rate variability using the calculation of the Baevsky stress index (SI).

CardiometryHeart rate variabilityBaevsky stress indexGame Sand Modeling (GSM)Psychological correctionSelf-developmentSelf-control

Original research

Using the method of mathematical planning of the experiment in the development of a quality control method of aerva lanata l. herb

Viloyatkhon N. Abdullabekova, Vosil R. Khaydarov, Saodat T. Sharipova, Oygul Rakhim qizi Rakhimova, Aipashsha J. Tajieva

Today, among the urgent tasks facing the pharmaceutical science of the Republic of Uzbekistan is the study of introduced medicinal plants.

Aerva lanata herbExtractionSum of flavonoidsExperiment designStatistical analysisPlanning matrix

Original research

Nature and structure of thoracoabdominal injuries

Gulomidin M. Khodzhimatov, Sardorbek M. Yakhyoev

This article presents the incidence, nature and structure of thoracoabdominal injuries in two major districts of the Andijan region.

Thoracoabdominal injuriesMortalityISS scale

Case report

Acute myocardial infarction following COVID-19 vaccination: a cause or a coincidence?

Ahmed A. Elheet, Mohamad H. Farrag, Mohamed M. Elkeliei, Ali M. Alabdali

Acute Myocardial Infarction (AMI) is a fatal condition with a subsequent variety of complications. Recently, COVID-19 vaccine has become an essential precaution to avoid infection.

COVID-19Acute myocardial infarctionSTEMIAstraZenecaVaccination

Original research

Assessment of E-learning readiness among different levels of Nursing Learners in KING SAUD MEDICAL CITY

Ahmad Haimour, Ahmad Alkhaibary, Hussein Alabssi, Mohammed Al Tous, Amal Alqarni, Mona Saleh, Sadiah Alshehri

Nurses’ and students’ willingness to increase information and practical skills through electronic platforms may help in setting up hundreds of timesaving and economical e-learning programs.

E-learningReedinessNursing learnersKing Saud Medical CityNursing levels

Original research

Behavioral shift of generation x towards OTT during covid’19 in India

Saatvik Sridhar, Pushkar Phadtare

Over-the-top (OTT) services such as Netflix, Prime Video, Disney+ Hotstar, Zee5, etc., have changed consumers' content consumption behavior.

Over the Top (OTT)Generation XCOVID-19CoronavirusImpact of CovidShift towards OTTOnline content consumption

Review

A review of work-life and well-being of parents

Sucheta Mandal, Vinita Sinha

The transition from office to work-from-home (WFH) has lead to an increased interest in the effects of this transition, not only on the quality of work obtained but also on the mental health of individuals. Research in this topic is expanding with different perspectives in focus.

ParentsMental healthWork from homeWell-beingVirtual officeTeleworking

Review

Mitochondrial therapy: a vision of the outlooks for treatment of main twenty-first-century diseases

Oleg I. Kit, Elena M. Frantsiyants, Irina V. Neskubina, Alla I. Shikhlyarova, Irina V. Kaplieva

Mitochondria are dynamic organelles which constantly change their shape, size, and location within the cells. Mitochondrial dynamics is associated with mesenchymal metabolism or epithelial-mesenchymal transition to regulate the stem cell differentiation, proliferation, migration, and apoptosis.

MitochondrialTherapyCancerTreatmentCell

Original research

Biological effects of mitochondrial therapy: preventing development of myocardial infarction and blocking metastatic aggression of B16/F10 melanoma

Oleg I. Kit, Elena M. Frantsiyants, Alla I. Shikhlyarova, Irina V. Neskubina, Irina V. Kaplieva, Natalia D. Cheryarina, Alexandra A. Vereskunova, Lidia K. Trepitaki, Yulia A. Pogorelova, Valeria A. Bandovkina, Ekaterina I. Surikova, Polina S. Kachesova, Elena A. Sheiko, Inga M. Kotieva, Marina A. Gusareva, Roza G. Luganskaya, Ekaterina S. Bosenko

The aim is to evaluate the physiological parameters of the efficacy of cardiac mitochondria transplantation in male mice with chronic neurogenic pain and B16/F10 melanoma growth.

Mitochondrial therapyMitochondriaHeartMyocardial infarctionB16/F10 melanomaChronic neurogenic painMale mice

Original research

Development of adaptive stereotactic radiotherapy method in treatment of primary malignant glial tumors in the brain

Stanislav G. Vlasov, Marina A. Yengibaryan, Alla I. Shikhlyarova, Pavel G. Sakun, Vitaly I. Voshedsky, Olga G. Rodionova, Elena A. Karnaukhova, Anna A. Solntseva, Vladislav E. Khatyushin, Olga V. Pandova, Natalia S. Kuznetsova, Sergey N. Kabanov, Maria A. Teplyakova

At present, there are some scattered evidence data pertaining to the use of an adaptive technique of radiotherapy in treatment of malignant glial tumors of the brain.

Malignant glial tumorsAdaptive stereotactic radiotherapy

Original research

Multiple factor analysis applied to calculation of blood pressure based on pulsometry data

Igor S. Yavelov, Georgy L. Danielyan, Andrey V. Rochagov, Anatoly V. Zholobov

Development of algorithms capable of determining arterial pressure (AP) according to the contour of a pulse wave (PW) remains a topical issue to be solved with long-time efforts by researchers who work for many years in the field of hemodynamics.

Multiple factor analysisPulsometryFiber optic pulse wave sensorsArterial pressureAge-related spline database of radial artery pulse waves

Case report

A low dose of amiodarone-indused sinoatrial node dysfunction: a case report

Ayurzana A., Avirmed A., Avarzed A., Batkhuu B., Amgalanbaatar D.

We recently treated a case similar to that reported by Mun et al and Chinushi M. Holter ECG demonstrated paroxysmal atrial fibrillation, frequent ventricular ectopy’s, atrial tachycardia. The patient complained of palpitation.

AmiodaroneLow doseSinoatrial node dysfunctionSide effects

Original research

Study of sedative activity and sleeping effect of the Zopnik mullein-shaped herb (Phlomis Thapsoides (BGE), growing in Uzbekistan

Orifjonova Gulnoza Kobiljon qizi, Manzura T. Mullajonova, Abdumumin K. Ganiev, Malika K. Tursunova

The sedative activity of the zopnik herb on the model of prolongation of the sleeping action of barbiturate in white rats was studied.

ProlongationRegel's zopnikMullein-shaped zopnikSedative activitySleeping effect

Original research

Depression: a predictor of coronary heart disease in Saudi Arabia

Ali S. Alshahrani, H. Korairi, A.Y. Sharifi, M. A. M. Alqahtani, S. A. AL Qahtani, K. M. A. Ahamed, A. Kaabi, O. M. Alzahrani, A. Y. Abouelyazid

This research study mainly deals to evaluate the effect of depression in coronary heart disease patients.

Hamilton depression rating scaleCoronary disease

Retrospective Cohort Study

Association between vitamin d status and subclinical hypothyroidism

Jaber Alfaifi, Waleed Abdalrazig Dosogi Elzain, S. Alshahrani, Khalid Tahir Ibrahim Mohamed Soliman, H. Korairi, A. Y. Abouelyazid

The purpose of this study is to investigate the relation between Vitamin D levels and sub-clinical hypothyroidism and the effect of Vitamin D supplementation on treatment outcome.

Subclinical hypothyroidismVitamin DThyroid-stimulating hormoneThyroid peroxidase antibodies

Original research

Perfect home composting of biodegradable waste resources for reducing carbon foot print and climate change associated with global warming – a microbiological approach

Manikprabhu N. Dhanorkar, Apurva Sabnis, Sharad P. Kale

Huge amounts of organic biodegradable waste resources are thrown on dumping yards in India and neighboring Asian countries every day. It is estimated that 40-50% of total solid waste collected daily is biodegradable in India. Mumbai, a 1% population of the country, generates about 2500 MT of biodegradable waste.

Solid waste resourceRecyclingHome compostingGlobal warmingClimate changeBio-methaneAerobic compostingSegregationBacterial compostingInsect-free compostingResponsible citizens

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Cardiometry: Training & Refreshing

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