№21 Февраль 2022

Моделирование патологических процессов

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Editorial

Addressing our current topics: Modeling of Pathological Processes

Modern medicine is now facing a huge number of challenging issues, which are associated with the present- day circumstances: the gap between rich and poor countries in public health care and a new virus pandemic with actualizing of vaccination so that all this unfavorable combination has become an obstacle in developing fundamental medicine areas like cardiology and oncology.
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Original research

Influence of diabetes mellitus on free radical processes in the heart in rats with Guerin’s carcinoma and characteristics of malignant lesions depending on the gender of animals

To study the intensity of lipid peroxidation (LPO) and the activity of the main antioxidant protection enzyme: superoxide dismutase (SOD) in heart tissues and tumors in rats of both genders with Guerin’s carcinoma (GC) and the tumor growth against the background of diabetes mellitus (DM).
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Short report

Decision support system in radiology for fast diagnostics of thoracic diseases under COVID-19 pandemic conditions

In the present article the relevance of using DSS under the current conditions for image recognition and, as a more specific application, for the purpose of additional assistance rendered to medical experts (radiologists) in their decision-making and preparing findings upon assessment of X-ray images is considered.
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Report

Photometric recorder of the carotid artery pulse wave with a system for stabilizing the clamping force

Preventive monitoring, which increases the possibility of diagnosing and curing a disease at an early stage, is interesting and relevant in medical diagnostics. Recently, both minimally invasive and non-invasive diagnostic techniques have become widespread.
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Original research

Predictors of residual coronary artery disease after PPCI in diabetic patients with STEMI

Objective: To describe the patients’ characteristics and risk factors of diabetic and non-diabetic patients presenting with ST-elevation myocardial infarction (STEMI) in relation to residual SYNTAX score after PPCI (primary PCI).
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Original research

Features of the course of cardiovascular diseases against the background of COVID-19

Based on the analysis of 308 electronic medical records of patients with a confirmed diagnosis of a new coronavirus infection COVID-19, the features of the course of cardiovascular diseases at the regional level were studied. It was found that in patients with cardiovascular diseases, the severity of the course and mortality are higher than in patients without cardiac pathology.
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Original research

Anatomical and topographical features of the gracilis muscle of the thigh from the position of using it for autotransplantation

Autotransplantation of a free flap of the gracilis muscle is currently actively used in reconstructive surgery for persistent prosoplegia, injuries of the brachial plexus, for plastic closure of defects in the upper lip, and in the treatment of pelvic sepsis. This study provides important information about the anatomical features of the gracilis muscle and its neurovascular bundle, which are highly variable.
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Original research

Mechanisms of cancellation by pain of genetically determined inhibition of a malignant tumor growth in experiment

Aims are to study the nature of the processes of carcinogenesis of experimental B16/F10 melanoma in uPA gene knockout mice modified by chronic neurogenic pain and investigate some electrophysiological mechanisms of melanoma development.
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Original research

Modifying effect of obesity on the content of sex hormones and their receptors in endometrial adenocarcinoma and its surrounding tissue

To study the effect of comorbid pathology: obesity of degree 2-3 on the level of sex steroid hormones and their receptors in the tumor and its surrounding tissue in patients with endometrial cancer (EC).
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Original research

Gas exchange readjustments in response to hypoxia and hypercapnia exposure in Magadan region military service draftees

Our study identified gas exchange and external respiration characteristics during hypoxia and hypercapnia exposure in young men of the Magadan Region.
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Original research

Impact of 3D transesophageal echocardiography assessment of mitral valve on short-term outcome of Balloon Mitral Valvuloplasty using additional quantitative parameters

The goals of this prospective observational study were to identify quantitative morphological factors that might aid in the prediction of PBMV outcome, as well as to define the function of 3D TEE in mitral valve evaluation.
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Report

Development of modern technology for obtaining tinctures with sedative effect

The aim of this work was to experimentally select the optimal conditions for obtaining a tincture with an effective sedative effect consisting of a mixture of common motherwort grass, medicinal lemon balm and nettle leaves in a ratio of (1:1:1) and the development of quality criteria for the finished product.
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Original research

The state of the cardiovascular system in women during pregnancy

The work is devoted to the study of the impact of pregnancy on the state of the cardiovascular system in women. The process of pregnancy is accompanied by significant changes in the rhythm of the heart performance and blood pressure, and the duration of the ECG waves and segments are not significantly fluctuated.
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Original research

Functional state of the students’ cardiovascular system under the conditions of mountain hypoxia

The article presents the functional state of the cardiovascular system of students under conditions of high-altitude hypoxia. From the analysis of the results of our research, it can be argued that due to the fact that students live under conditions of a reduced oxygen content in the atmospheric air, there is a significant increase in the systolic output of their hearts.
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Original research

Relationship between comorbid pathology and tumor progression. Morphological portrayal of internal organs in modeling the growth of Guerin’s carcinoma under diabetic conditions

An increase in the incidence of malignant tumors progressing against the background of various comorbid pathologies determines the need to study the mutual influence of pathological processes using experimental modeling.
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Original research

Development of an experimental model of tumor growth under hypothyroidism

Our aim has been to develop an experimental model of the tumor growth against the background of hypothyroidism in rats of both genders in order to study possible influence made by hypothyroidism on progression of malignant tumors of various histological types.
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Original research

Cognitive, emotional-affective, anxiety and autonomic disorders in patients with a new coronavirus infection (covid-19) in the acute period

The purpose of this work is to identify neuropsychiatric functions in patients at Department No. 1 responsible for medical care of patients with a new coronavirus infection at the Samara City Hospital No. 7. Appropriate scales and questionnaires were used for this purpose.
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Report

Nutritional and biological value of natural-bio shoots mung bean “Mungoltin”. Food and biological values

Based on the results of our own research, examination of scientific dossier materials and reference literature data, it was established that dry powder Mungoltin made from the shoots of mung beans produced by Oriona-Scorpion LLC (Uzbekistan) contains a sufficient amount of protein, minerals, vitamins and dietary fiber, does not have a negative impact on the health status of experimental animals and does not result in functional and material cumulation.
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Short report

Pre-angioplasty instantaneous wave-free ratio pullback predicts hemodynamic outcome in diffuse coronary artery disease

Serial stenoses or diffuse vessel narrowing hamper pressure wire–guided management of coronary stenoses. Characterization of functional relevance of individual stenoses or narrowed segments constitutes an unmet need in ischemia- driven percutaneous revascularization.
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Original research

Prevalence of anxiety and depression disorders among medical students one year after the start of the COVID-19 pandemic

The aim is to study the incidence rate of anxiety and depressive disorders and their relationship with the everyday activity at the H.M. Berbekov Kabardino-Balkarian State University (KBSU) medical faculty students a year after the start of the Covid-19 pandemic.
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Original research

Features of life activity and the incidence rate of anxiety and depressive disorders among medical students studying remotely during the epidemic of a new coronavirus infection (Covid 19)

The aim is to study the features of life and the incidence rate of anxiety and depressive disorders among medical faculty students studying remotely during the epidemic of a new coronavirus infection (Covid 19) at the Kabardino-Balkarian State University named after H.M. Berbekov.
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