Treatment and prevention of cardiovascular system diseases:
system oriented approach vs. local control

It is shown that the mechanism of action of magnetic fields at body level is based on the development of unspecific adaptational reactions of the body - stress and anti-stressor reactions; elevated activation, calm activation and training.

The aim of this article is a comprehensive review of the publications during the last decade in order to evaluate current indications for cardiac resynchronization therapy (CRT) in patients with heart failure (HF) and atrial fibrillation (AF).

Lyubov Mikhailovna Garkavi’s research opened a new scientific field based on the discovery of Pattern of development of qualitatively differing general unspecific adaptational reactions of the organism / Scientific Discovery Registration Certificate No. 158 issued by the Committee on Inventions and Discoveries at the Council of Ministers of the USSR, 1975). Her colleagues, companions and both friends E.B. Kvakina and M.A. Ukolova were among the co-authors of the discovery.

The paper presents a brief review on how some concepts on the organism general adaptational reactions developed, including their role in increasing the unspecific resistance in the organism. Demonstrated is periodicity of the patterns of anti-stressor type reactions (training, calm and elevated activation) and stress in a wide range of stimulation values.

The paper highlights the key stages on the way of a proper understanding of the magnetic field anti-tumor influence mechanisms on the level of an organism as an integrated system and its individual subsystems.

Knowledge of laws of the different organism reactions to external and internal influences in case both of general unspecific adaptational reactions of different types and the periodic system of the repetitive pattern reactions offers us a possibility to target and control the organism resistance level using the activation therapy methods. Given are some examples of using the available biologically active means and the programmed modes of their dosing which demonstrate simplicity and efficacy of the stable health state restoration and maintenance.

The paper reveals logical relationships between events, facts and results of research studies and exemplary materials of practical applications of the adaptational reactions. It is demonstrated that the stress reaction by H. Selye and the anti-stressor type adaptational reactions by L. Kh. Garkavi, E.B. Kvakina and M.A. Ukolova have become the cornerstone in development of scientifically grounded approaches to control of the organism states.

The paper describes some concepts on processes occurring in the neuroendocrine and immune systems during development of general unspecific adaptational reactions.

The paper offers an analysis of activation therapy approaches to an increase in efficacy of antitumor treatment with the use of electromagnetic-nature factors as developed by L.Kh. Garkavi and E.B.Kvakina.