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The assessment of Dystrophin and Titin in premenopausal thyroid women patients

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The aim, this study was designed to investigate the relationships between Dystrophin and Titin in patients with thyroid dysfunction. Materials and methods. The study included 90 patients; aged between 15 and 45 years, divided into three groups, 60 patients with thyriodism and 30 healthy subjects were taken as control group, all patients (n=60) were divided into two groups hypothyroidism and hyperthyroidism. This cross-sectional study was carried out in Al-Fadel foundation for training and development (research foundation) in Babylon province. Using 5 ml disposable syringes, healthy controls and patients were randomly punctured for blood samples. Blood was placed in a centrifuge tube and allowed to coagulate for 15 minutes before being spun for 10 minutes at 1000 xg to 2000 xg to separate the serum for immunological testing. Results. The Mean Serum Titin levels which indicated significant differences in studied groups of hypothyroidism, and hyperthyroidism patients, and the control groups. Remark that Titin levels decreased in Hypothyroidism and hyperthyroidism groups less than in the healthy control group. The statistical analysis results of Serum Dystrophin levels found significant differences in the three groups studied. These results revealed a significant decline in hypothyroidism patients, and hyperthyroidism patients, compared with the healthy control group, while Dystrophin level was increased in hypothyroidism more than in the hyperthyroidism patients. Conclusion. The results of T3, T4 &TSH level showed significant differences after the comparison between hyperthyroidism, hypothyroidism and control. There are significant differences in the levels of DMD and TTN in comparison between Hyperthyroidism, and Hypothyroidism as well as with control.


Zahraa Shakir Mahmod, Haider Salih Jaffat. The assessment of Dystrophin and Titin in premenopausal thyroid women patients. Cardiometry; Issue No. 26; February 2023; p. 236-241; DOI: 10.18137/cardiometry.2023.26.236241; Available from: dystrophin-titin


Thyroid disorders,  Dystrophin (DMD),  Titin (Human TTN)
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