Heart-Type Fatty Acid Binding Protein as Potential Biomarker for Acute Myocardial Infarction

Atindra Narayan^1*, Sumit Pundir², Rashmi Tirkey³

¹ Department of medicine, SGT University
Gurugram, Haryana, India

² Department of Pharmacy, Sanskriti University
Mathura, Uttar Pradesh, India

³ Department of Health & Allied Science, Arka Jain University
Jamshedpur, Jharkhand, India

* Corresponding author

[email protected]

Abstract

Acute myocardial infarction (AMI) is the most recurrent heart emergency which can lead to morbidity and death. During infarction, the heart releases cytoplasmic protein in the blood. These proteins such as creatine kinase, troponin and Heart type fatty acid binding protein (H-FABP) are used as indicators to spot cardiovascular arrest. This research paper aims to evaluate the efficiency, specificity and sensitivity of biomarkers in determining the AMI. This paper shows the use of direct sandwich ELISA technique to determine the level of H-FABP released in early stage of AMI. 50 suspected AMI subjects were used to observe the specificity, sensitivity and diagnostic efficacy. The study also discusses the correlation of the concentration of H-FABP in confirmed AMI, non AMI and normal subjects.

Imprint

Atindra Narayan, Sumit Pundir, Rashmi Tirkey. Heart-Type Fatty Acid Binding Protein as Potential Biomarker for Acute Myocardial Infarction. Cardiometry; Issue 23; August 2022; p.820-824; DOI: 10.18137/cardiometry.2022.23.820824; Available from: https://www.cardiometry.net/issues/no23-august-2022/acid-binding-protein

Keywords

Acute Myocardial Infarction (AMI), Cardiovascular arrest, Creatine kinase, Heart attack, H-FABP

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