Evaluation of general repolarization of cardiomyocites with biphasic pulses of different shapes

Abstract

According to data provided by the European Resuscitation Council (ERC), 76% of sudden cardiac arrests should be attributed to ventricular fibrillation [1-3]. The main treatment of this disease is an immediate cardiopulmonary resuscitation, one of the components of which is a defibrillation of abnormal rhythms.

The paper presents an analysis of advanced shapes of biphasic pulses, which have found a widespread application and have been clinically tested. The aim is to study the main parameters of the impact of different shapes of the existing pulses and their due consideration in a development of a defibrillator. An evaluation has been performed using defibrillators Fluke Impulse 7000DP and device Impulse 7010 designed to simulate different loads. Evaluated has been the shape of each of 7 biphasic pulses, the amplitude and exposure time of each of different signal phases. Upon results of the conducted analysis, some recommendations on cardiopulmonary resuscitation have been prepared; in particular, the necessity to maintain a constant current density of 14 -16 A, delivered for 4 -5 ms, is proposed. The maintenance of these parameters can be provided using the current stabilization technology (CST).

Imprint

Nikolay N. Chernov, Aleksandr A. Bezverkhii, Vladimir I. Timoshenko. Evaluation of general repolarization of cardiomyocites with biphasic pulses of different shapes. Cardiometry; Issue 16; May 2020; р.80-84; DOI: 10.12710/cardiometry.2020.16.8084; Available from: http://www.cardiometry.net/issues/no16-may-2020/evaluation-of-general-repolarization