Neurophysiological status and adaptation responses upon application of electromagnetic fields in complex treatment of patients with malignant gliomas of the brain
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The aim of this paper is to discover some advantages and benefits of the complex treatment of patients with malignant gliomas of the brain with the use of electromagnetic field therapy.
Materials and methods
Our examination focused on patients suffering from malignant gliomas of the brain. One cohort of them (the reference group covering 30 patients) received surgery and chemoradiotherapy (CHRT) without electromagnetic field exposure of the brain, while the other group (the main test group which included 30 individuals) was subjected to the same therapy, but accompanied by the electromagnetic field treatment of the brain. Varying and permanent magnetic field exposure sessions were carried out from day 1 till day 20 in the context of the complex therapy. All in all, every patient received 4 courses of the systemic chemotherapy, with an interruption of 4 weeks, in combination with exposures to electromagnetic field applied to the brain area. An assessment of efficacy of the adjuvant chemoradiotherapy was performed upon expiration of 12-14 days from the date of the last injection of chemotherapy drugs according to applicable WHO recommendations for standardizing in assessment of treatment outcomes.
An application of the combined magnetotherapy, which includes both the central and local electromagnetic actions, in the treatment of malignant gliomas of the brain results in a statistically significant increase in the general and recurrence-free two-year survival, improves the scale grade level of the ECOG/WHO performance status grading and the Karnofsky index according to the Karnofsky performance status scale, provides for reduction of neurological toxicity symptoms and makes a pronounced anti-stressor effect, namely, leads to predominance of the reactions of training, calm and elevated activation in the framework of adaptation reactions of the physiological types.
The central and local actions by ultra-low frequency magnetic field (ULF MF) used in the therapy of malignant gliomas of the brain should be considered as a trigger of the neuro-hormonal regulation that is favorable for reducing toxicity influence by chemoradiotherapy on the brain and that is beneficial for improving life quality and prolonging a life span for the above patients.
Oleg I. Kit, Dmitry P. Atmachidi, Alla I. Shikhlyarova, Eduard E. Rostorguev, Marina A. Engibaryan, Yulia V. Ulyanova, Tatiana P. Protasova, Yulia Yu. Arapova, Elena P. Korobeinikova. Neurophysiological status and adaptation responses upon application of electromagnetic fields in complex treatment of patients with malignant gliomas of the brain. Cardiometry; Issue 11; November 2017; р.78–84; DOI: 10.12710/cardiometry.2017.11.7884; Available from: http://www.cardiometry.net/issues/no11-november-2017/neurophysiological-status