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Original research

Morphologic correlates of the multimodal electromagnetic exposures efficiency (as exemplified by the experiment tumor growth)

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Aim

The aim of the present paper is to study the morphofunctional changes in the tumor tissue and peripheral zone in experimental animals under the influence of extremely high-frequency electromagnetic radiation (EHF EMR). Combined effect of EHF EMR and ultra-low-frequency magnetic field (ULF MF) without the use of special anti-tumor agents is to be studied as well.

Materials and methods

The experiments have been performed on 56 outbred male rats with inoculated sarcoma 45. Low intensity EHF EMR and ULF MF exposures have been carried out only on animals’ heads. Histological and morphometric study of the sarcoma 45 tumor tissue and its peripheral area has been performed.

Results

In case of the combined electromagnetic exposure (in 65% of cases) against the background of the sTable anti-stressor adaptation reactions an evident anti-tumor effect has been observed. Under effective combined electromagnetic action, lymphocyte infiltration of the tumor tissue and its peripheral zone was enhanced not only in comparison with the reference group, but also compared to the EHF EMR monoexposure.

Conclusion

Thus, significant enhancement of the tumor tissue infiltration by leukocyte cells under the combined effect of EHF EMR and ULF MF may indicate mobilization of the local immune mechanisms due to the activation of the neuroendocrine and immune system organs.

Imprint

Tatiana A. Barteneva, Alla I. Shikhlyarova, Galina V. Zhukova, Tatiana P. Protasova, Marina I. Bragina, Elena A. Shirnina. Morphologic correlates of the multimodal electromagnetic exposures efficiency (as exemplified by the experiment tumor growth). Cardiometry; Issue 11; November 2017; p.48–53; DOI: 10.12710/cardio­metry.2017.11.4853; Available from: http://www.cardiometry.net/issues/no11-november-2017/multimodal-electromagnetic-exposures-efficiency

Keywords

Electromagnetic exposure,  Antitumor effect,  Tumor infiltration,  Antistressor adaptation reaction
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