Adhesive phytoadaptogens-geroprotectors in preventive oncology

O.A. Bocharova^1*, R.V. Karpova¹, E.V. Bocharov¹, A.A. Aksyonov¹, T.L. Chekalina², S.V. Chulkova¹, N.S. Ionov³, I.V. Kazeev¹, M.A.Lyzhenkova⁴, A.A. Vershinskaya⁵, V.G. Kucheryanu⁶, V.S. Kosorukov¹

¹ Blokhin National Medical Research Center of Oncology, Kashirskoe shosse 24, Moscow, 115478 Russia

² Moscow State University of Medicine and Dentistry named after A. I. Evdokimov, Delegatskaya st., 20/1, Moscow, 127473, Russia

³ Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Bldg. 8, Moscow, 119121 Russia

⁴ Russian National Research Medical University named after N. I. Pirogov, st. Ostrovityanova, 1, Moscow, 117997, Russia

⁵ Russian Scientific Center of Surgery named after academician B.V. Petrovsky, Oktyabrsky prospect, 3, Troitsk, Moscow, 108840, Russia

⁶ Research Institute of General Pathology and Pathophysiology, Baltiyskaya Str.,8, Moscow, 125315, Russia

* Corresponding author

[email protected]

Abstract

At the current stage of medical science development there is significant knowledge about various disorders in the tumor process (expression of oncogenes and cytokines, factors of apoptosis, drug resistance, angiogenesis, deficiency of immunoreactivity, etc.). Many of the identified features of the tumor cell are trying to be used as targets for anticancer therapy. However, it is problematic to consider these numerous “details” of the characteristics of a tumor cell as targets for anticancer therapy. This is due to the fact that they do not have a key or independent significance in the appearance of a tumor cell, although they can work in experimental animal models under certain conditions and with prolonged therapy, which at times has little relation to humans.

Imprint

O.A. Bocharova, R.V. Karpova, E.V. Bocharov, A.A. Aksyonov, T.L. Chekalina, S.V. Chulkova, N.S. Ionov, I.V. Kazeev, M.A.Lyzhenkova, A.A. Vershinskaya, V.G. Kucheryanu, V.S. Kosorukov. Adhesive phytoadaptogens-geroprotectors in preventive oncology. Cardiometry; Issue 26; February 2023; p.55-68; DOI: 10.18137/cardiometry.2023.26.5568; Available from: https://www.cardiometry.net/issues/no26-february-2023/adhesive-phytoadaptogens-geroprotectors

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