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Original research

Drug safety among Hypertensive patients treated with antihypertensive drugs in Tertiary care Teaching Hospitals

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Abstract

Introduction:- Hypertension is one of the essential health problems Worldwide. According to JNC I to VIII guidelines treatment of hypertension with various type of antihypertensive drugs either mono therapy or combination therapy is updated time to time. Selection of a drug is often based on the benefit-risk ratio is also called drug safety even no one drug has totally safe and can be measured on the basis of occurrence of beneficial effect verses Adverse effect. The reporting of ADRs in nations is still low as comparison to providing 10% of total medication in the world. So the present study is proposed on entitled Drug safety among Hypertensive patient treated with antihypertensive drugs in Tertiary care teaching Hospitals. 2.Materials and Methods:- This was a prospective and observational study carried out in the department of Pharmacology, Santosh Medical College and Hospital, Ghaziabad in collaboration with Department of Medicine, Muzaffarnagar Medical College, Muzaffarnagar, A total 234 hypertensive patient of both gender and age above 18 years treated with any types of antihypertensive drug were selected for the study. ADRs were recorded and evaluated with the help of ADRs form uploaded by CDSCO-PvPI of whose causality assessment and severity score that were calculated by appropriate scale and .3.Observation and Results:- A total 16.67% of prevalence of ADRs were found in this study of whose Risk/Benefit were calculated and found that ARBs and BBs groups were the safest group of antihypertensive drug with smallest number of ADRs prevelance 14.14% and 15.15% with risk benefit ratios 0.16 and 0.18 respectively.5. Conclusion:- The results of the above study would be useful for the physicians in rational selection of drug therapy for treatment of hypertensive patients. The present data suggest that the ADRs monitoring needs to be done in hospital settings continuously so that untoward effect caused by different medicines can be identified and documented to make better health care system and to stop further burden of unnecessary use of drug by patients health care system.

Imprint

Lalendra Yadav, Shaktibala Dutta, Jyotsna Sharma, Ila Pahwa, Vaishali Lotte, Amit Kumar. Drug safety among Hypertensive patients treated with antihypertensive drugs in Tertiary care Teaching Hospitals. Cardiometry; Issue 25; December 2022; p.1349-1355; DOI: 10.18137/cardiometry.2022.25.13491355; Available from: https://www.cardiometry.net/issues/no25-december-2022/drug-safety-among-hypertensive

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