Comparative analysis of anti-fungal properties of carbohydrates derivatives over commercial antifungal drugs
Aim:The goal is to compare the anti-fungal characteristics of carbohydrates derivatives to commercial antibiotics, and docking will be used to see how the ligand, protein, and anti-fungal interact molecularly. Materials and methods:The protein structure was obtained from the PDB (protein data bank) website, while the ligand structure was obtained from the NCBI-PubChem website. The fungus from aspergillus parasiticus (3HQR) as a protein, gluconolactone as a ligand, and benzimidazoles as an antifungal are the three different types of chemicals employed for docking. The genuine nature of protein chemical structure may be found on the PubChem website, while the remaining two chemical structures of ligand and antifungal can be found on the PDB website. Result:To determine whether or not the interaction between the protein molecule of the fungus from aspergillus parasiticus (3HQR) and the antifungal benzimidazoles is correct. The independent sample t-test was used to compare binding affinity using SPSS software. Significant difference, one-sided p values are.18-.001, and the two-sided p-value is.689 -.001, according to statistics. Conclusion: The antifungal benzimidazoles appear to be more specific and selective in their antifungal activity against the target protein.
Kvs meghana, Sivaprasad. Comparative Analysis of Anti-Fungal Properties of Carbohydrates Derivatives over Commercial Antifungal Drugs . Cardiometry; Issue 25; December 2022; p.1570-1576; DOI: 10.18137/cardiometry.2022.25.15701576; Available from: https://www.cardiometry.net/issues/no25-december-2022/comparative-analysis-anti-fungal-properties