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Original research

Mitochondrial therapy: direct visual assessment of the possibility of preventing myocardial infarction under chronic neurogenic pain and B16 melanoma growth in the experiment

* Corresponding author

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Abstract

On models of chronic neurogenic pain (CNP) and the growth of a malignant tumor (metastasizing B16 melanoma) in male mice, we studied an effect produced by mitochondrial therapy (MCT) on the state of the myocardium. Some structural correlates of the compensatory-restorative effect by mitochondria transplanted from healthy recipient rats were revealed. It has been identified that MCT contributes to the preservation of the structural integrity of the myocardial tissue, the inclusion of an auxiliary link in the cellular mechanisms of tissue restoration: fibroblasts, histiocytes, lymphocytes, eosinophils and other connective tissue elements, which implement the intercellular mechanism of information transfer that provides the external regulatory function of MCT. The ability of mitochondria to prevent the DNA decay determines the possibility of initiation of the operation of the nuclear mechanisms of the cardiomyocyte division, which is characteristic of a population of young cells and which indicates the determining position of exogenous mitochondria.

Imprint

Oleg I. Kit, Alla I. Shikhlyarova, Elena M. Frantsiyants, Irina V. Neskubina, Irina V. Kaplieva, Gаlina V. Zhukova, Lidia K. Trepitaki, Yulia A. Pogorelova, Valeria A. Bandovkina, Ekaterina I. Surikova, Ivan A. Popov, Tamara Voronina, Oksana V. Bykadorova, Elizaveta V. Serdyukova. Mitochondrial therapy: direct visual assessment of the possibility of preventing myocardial infarction under chronic neurogenic pain and B16 melanoma growth in the experiment. Cardiometry; Issue 22; May 2022; p.38-49; DOI: 10.18137/cardiometry.2022.22.3849; Available from: https://www.cardiometry.net/issues/no22-may-2022/mitochondrial-therapy-direct

Keywords

Laboratory mice,  Chronic neurogenic pain,  B16 melanoma,  Mitochondrial therapy,  Myocardium,  Pathomorphology,  Cardiac microscopy
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