Cardiotoxicity: a challenge for modern oncology

Oleg I. Kit¹, Elena M. Frantsiyants¹, Elena A. Dzhenkova¹, Oksana V. Katelnitskaya¹, Alla I. Shikhlyarova¹, Aleksandr B. Sagakyants¹, Ekaterina V. Verenikina¹, Yuriy А. Gevorkyan¹, Yuriy А. Fomenko¹, Vladimir S. Trifanov¹, Aleksey N. Shevchenko¹

¹ Rostov Research Institute of Oncology, Ministry of Healthcare of the Russian Federation

Russia, 344037, Rostov-on-Don, 14th Line st. 63

* Corresponding author

[email protected]

Abstract

The article provides a modern vision of the problem of cardiotoxicity in oncology. Integrity and generality of nodal pathogenetic events in the body in case of carcinogenesis, antitumor therapy and cardiopathology are caused by similar mechanisms at different hierarchical levels. Identity of potential risk factors, including inflammation, aging, obesity, diabetes and smoking, has been noted.

Imprint

Oleg I. Kit, Elena M. Frantsiyants, Elena A. Dzhenkova, Oksana V. Katelnitskaya, Alla I. Shikhlyarova, Aleksandr B. Sagakyants, Ekaterina V. Verenikina, Yuriy А. Gevorkyan, Yuriy А. Fomenko, Vladimir S. Trifanov, Aleksey N. Shevchenko. Cardiotoxicity: a challenge for modern oncology. Cardiometry; Issue 13; November 2018; p.8-14; DOI: 10.12710/cardiometry.2018.13.814; Available from: http://www.cardiometry.net/issues/no13-november-2018/cardiotoxicity

Keywords

Cardiotoxicity, Cardiopathology, Carcinogenesis, Trastuzumab, Tissue homeostasis, Antitumor effect

Download PDF

Current issue