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Systematic review

Antidepressant’s long-term effect on cognitive performance and cardiovascular system

* Автор, отвечающий за переписку

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The nature of antidepressants and their adverse effects should be considered when treating severe depression in individuals with psychotic symptoms. Antidepressant prescription rates have risen steadily over the last 30 years, affecting people of all ages.


The goal of this study was to see if depression and antidepressant usage were linked to long-term changes in cognitive function and cardiovascular health.


Meta-analysis was performed using PRISMA guidelines along with using the SPIDER search framework using related keywords on different search engines i.e. Google scholars, PubMed, Scopus, ISI, etc. Total (n=2256) papers were obtained and assessed for eligibility. Altogether 15 studies were included using databases and other methods. The Newcastle-Ottawa Scale examined the grades provided by the data after numerous screenings.


A distinct link was found between antidepressants with cognitive performance and the cardiovascular system. Dementia and hypertension were prevailing long-term effects caused by frequent use of antidepressants in chronic and mild depression.


Ali Hassan Salman Nasser. Antidepressant’s long-term effect on cognitive performance and cardiovascular system. Cardiometry; Issue 23; August 2022; p.76-88; DOI: 10.18137/cardiometry.2022.23.7688; Available from:’s-long-term-effect

Ключевые слова

Depression,  Depressive disorder,  Antidepressants,  Long-term effect,  Cognition,  Cognitive performance,  Cardiovascular system
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