Structural oncomarkers in blood plasma in patients with multiple myeloma when using accompanying selective plasma exchange and chemotherapy

Abstract

The aim of this research work has been to investigate the structural organization of solid films made from blood plasma taken from patients with secretory multiple myeloma (MM) and identify some specific markers of the tumor process in them, when conducting selective plasma exchange and medication. Using the methods of wedge- and edge-shaped dehydratation, we have completed morphological screening of solid samples of blood plasma in 25 patients primarily diagnosed with multiple myeloma (MM).

The obtained results are characterized by profound disorders in the processes of self-organization with predominance of some pathological morphotypes of facias having systemic and local signs of intoxication and paraproteinemia, which correlate with their equivalents revealed in the respective biochemical tests. It has been found that development of multiple myeloma is accompanied by formation of some oncomarkers specific to this sort of oncopathology. The identification of the oncomarkers have been confirmed by the formation of the pathological aggregation of anisotropic micro- and macrospherolytes, which have demonstrated degenerative transformations upon completion of chemotherapy: they have been shaded because of producing complex compounds with chemotherapy drugs or metabolites of the latter.

Conclusion

By this means the cascade of the pathological events have been reflected in our screening morphological assays of blood plasma that is of great prognostic value and may be used in evaluation of efficacy of treatment of multiple myeloma.

Imprint

Alla I. Shikhlyarova, Natalia Е. Zuderman, Natalia D. Ushakova, Elena M. Frantsiyants, Irina А. Goroshinskaya, Irina V. Kaplieva, Irina V. Neskubina, Elena A. Sheiko, Irina B. Lysenko. Structural oncomarkers in blood plasma in patients with multiple myeloma when using accompanying selective plasma exchange and chemotherapy. Cardiometry; Issue 20; November 2021; p.21-28; DOI: 10.18137/cardiometry.2021.20.2128; Available from: https://www.cardiometry.net/issues/no20-november-2021/structural-oncomarkers