Applicability of mitochondrial energy factors in accompanying therapy of lymphoproliferative diseases (experimental study)

Abstract

The purpose of the study was to reveal the effectiveness of the Cytochrome C drug in the early stages of the Pliss lymphosarcoma growth in white outbred rats.

Materials and Methods

The studies were included white outbred male rats with an initial weight of 180-220 g (n=40) with subcutaneously inoculated Pliss lymphosarcoma. Rats in the main group received the Cytochrome C intraperitoneally in a single dose of 1.6 mg/kg 1 hour after the tumor inoculation and then until death; animals with tumors in the control group received saline instead of the studied drug in the same way and in the same dosage.

Results

Subcutaneous tumors appeared in the control group in 100% cases, in the main group in 55% cases; tumors were not detected in 45% of animals in the main group. In rats of the main group receiving experimental treatment, tumors regressed with time: in 73% cases with complete recovery of rats, in 27% cases animals died.

Conclusion

The Cytochrome C in a therapeutic and prophylactic regimen had a pronounced antitumor effect. Perhaps the effectiveness of the drug can be improved using an inert carrier which will protect the protein from proteolytic cleavage when it enters the bloodstream, together with detoxification agents.

Imprint

Elena M. Frantsiyants, Irina V. Kaplieva, Valerija A. Bandovkina, Lidia K. Trepitaki, Ekaterina I. Surikova, Irina V. Neskubina, Julija A. Pogorelova, Natalia D. Cheryarina, Alla I. Shikhlyarova, Tatiana I. Moiseenko, Maxim N. Duritskii, Sergey V. Tumanian, Yuriy V. Przhedetskiy, Viktoria V. Pozdnyakova. Applicability of mitochondrial energy factors in accompanying therapy of lymphoproliferative diseases (experimental study). Cardiometry; Issue 20; November 2021; p.29-33; DOI: 10.18137/cardiometry.2021.20.2933; Available from: https://www.cardiometry.net/issues/no20-november-2021/applicability-of-mitochondrial