A study on the role of inflammatory process of the aorta wall in the development, prognosis, and management of aortic aneurysms

Abstract

Objective: Abdominal Aortic aneurysms (AAA) are pathological aortic dilations that can rupture and result in up to 90% overall mortality. These lesions have a strong inflammatory substrate since atherosclerosis, which is undoubtedly related to inflammation, also predisposes patients to develop abdominal aorta aneurysms. The primary purpose of the research was to examine the role that inflammation in the aortic wall plays in the development, prognosis, and management of aortic aneurysms. Material and methods: This prospective, non-randomized investigation analyzed the cytosolic levels of interleukin-1b, interleukin-6, and tumor necrosis factor α (TNFα) in the walls of 57 individuals with aneurysms. Study group 1 consisted of patients with ruptured aneurysms (n=11), whereas study group 2 included patients with no symptoms from their aneurysms (n=32). There were 14 kidney recipients in the control group. Result: The walls of rupture aneurysms were shown to have larger and more pronounced inflammatory processes as well as higher levels of the cytokines cytokine IL6(P