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An analysis of the dynamic role of lipids in the progression and development of cardiovascular disease

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The main cause of mortality around the globe is cardiovascular disease (CVD). There are several indications followed by experimental validation that dysfunctional lipotoxicity is one of the primary causes of cardiovascular illnesses such as atherosclerosis, “coronary heart disease”, (CHD), and hypertension. Obesity and diabetes raise the number of circulating lipids, which may enhance the production of harmful intermediates and cause issues related to cardiovascular disorders. Effective and affordable medicines to lower cardiovascular risk are desperately required. Lipids or lipoprotein particles play a critical role in atherosclerosis, the pathophysiology behind CVD. They also have an effect on inflammatory processes, vascular or cardiac cell function, leukocyte activity, and ultimately the health of the heart and blood arteries. In this paper, an attempt was made to identify the cause of lipid buildup that led to the pathophysiology of cardiovascular disorders as well as the processes behind lipotoxicity. A summary of current and developing treatment approaches to decrease the incidence of lipid-induced cardiovascular disease is also compiled through previous studies.


Saad Mohammad Shakir, Aditya Mishra, S Kalaiselvi An Analysis of the Dynamic Role of Lipids in the Progression and Development of Cardiovascular Disease. Cardiometry; No.26 February 2023; p.390-397; DOI: 10.18137/cardiometry.2023.26.390397; Available from:


Atherosclerosis,  Cholesterol,  Cardiovascular disease (CVD),  Lipid,  lipoproteins,  Lipotoxicity
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